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[[Image:1npy.png|left|200px]]


{{STRUCTURE_1npy|  PDB=1npy  |  SCENE=  }}
==Structure of shikimate 5-dehydrogenase-like protein HI0607==
 
<StructureSection load='1npy' size='340' side='right'caption='[[1npy]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
===Structure of shikimate 5-dehydrogenase-like protein HI0607===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1npy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NPY FirstGlance]. <br>
{{ABSTRACT_PUBMED_15735308}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1npy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1npy OCA], [https://pdbe.org/1npy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1npy RCSB], [https://www.ebi.ac.uk/pdbsum/1npy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1npy ProSAT], [https://www.topsan.org/Proteins/MCSG/1npy TOPSAN]</span></td></tr>
[[1npy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPY OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/SHDHL_HAEIN SHDHL_HAEIN] In vitro, is able to catalyze the NADP(+)-dependent oxidation of shikimate to 3-dehydroshikimate. However, has much lower activity than classical shikimate dehydrogenases AroE, indicating that shikimate may not be the biological substrate. Cannot utilize NAD(+) instead of NADP(+). Is not able to catalyze the oxidation of quinate.<ref>PMID:15735308</ref>  
<ref group="xtra">PMID:015735308</ref><ref group="xtra">PMID:017649975</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/np/1npy_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1npy ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
[[Category: Collart, F.]]
[[Category: Large Structures]]
[[Category: Joachimiak, A.]]
[[Category: Collart F]]
[[Category: Korolev, S.]]
[[Category: Joachimiak A]]
[[Category: Koroleva, O.]]
[[Category: Korolev S]]
[[Category: MCSG, Midwest Center for Structural Genomics.]]
[[Category: Koroleva O]]
[[Category: Zarembinski, T.]]
[[Category: Zarembinski T]]
[[Category: Mcsg]]
[[Category: Midwest center for structural genomic]]
[[Category: Protein structure initiative]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Unknown function]]