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[[Image:1mn4.png|left|200px]]


{{STRUCTURE_1mn4|  PDB=1mn4  |  SCENE=  }}
==Structure of Ndt80 (Residues 59-340) DNA-binding domain core==
 
<StructureSection load='1mn4' size='340' side='right'caption='[[1mn4]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
===Structure of Ndt80 (Residues 59-340) DNA-binding domain core===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1mn4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MN4 FirstGlance]. <br>
{{ABSTRACT_PUBMED_12411490}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mn4 OCA], [https://pdbe.org/1mn4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mn4 RCSB], [https://www.ebi.ac.uk/pdbsum/1mn4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mn4 ProSAT]</span></td></tr>
==About this Structure==
</table>
[[1mn4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MN4 OCA].  
== Function ==
 
[https://www.uniprot.org/uniprot/NDT80_YEAST NDT80_YEAST] Transcription factor required for successful completion of meiosis and spore formation. Gets activated after completion of meiotic recombination at the end of prophase I. Recognizes and binds to the middle sporulation element (MSE) 5'-C[AG]CAAA[AT]-3' in the promoter region of stage-specific genes that are required for progression through meiosis and sporulation. Competes for binding to MSE with the transcriptional repressor SUM1, which represses middle sporulation-specific genes during mitosis and early sporulation.<ref>PMID:8524222</ref> <ref>PMID:9660952</ref> <ref>PMID:9742092</ref> <ref>PMID:12832469</ref>
==Reference==
== Evolutionary Conservation ==
<ref group="xtra">PMID:012411490</ref><references group="xtra"/>
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mn/1mn4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mn4 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Glover, J N.M.]]
[[Category: Glover JNM]]
[[Category: Lamoureux, J S.]]
[[Category: Lamoureux JS]]
[[Category: Stuart, D.]]
[[Category: Stuart D]]
[[Category: Tsang, R.]]
[[Category: Tsang R]]
[[Category: Wu, C.]]
[[Category: Wu C]]
[[Category: Ig fold]]
[[Category: Protein-dna complex]]
[[Category: Transcription]]
Retrieved from "https://proteopedia.org/1mn4"