1lru: Difference between revisions
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==Crystal Structure of E.coli Peptide Deformylase Complexed with Antibiotic Actinonin== | |||
<StructureSection load='1lru' size='340' side='right'caption='[[1lru]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1lru]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LRU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LRU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BB2:ACTINONIN'>BB2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lru OCA], [https://pdbe.org/1lru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lru RCSB], [https://www.ebi.ac.uk/pdbsum/1lru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lru ProSAT]</span></td></tr> | ||
[[1lru]] is a 3 chain structure with sequence from [ | </table> | ||
== Function == | |||
== | [https://www.uniprot.org/uniprot/DEF_ECOLI DEF_ECOLI] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163] | ||
< | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lr/1lru_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lru ConSurf]. | |||
<div style="clear:both"></div> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Blanc | [[Category: Blanc V]] | ||
[[Category: Chevrier | [[Category: Chevrier M]] | ||
[[Category: Dupuy | [[Category: Dupuy A]] | ||
[[Category: Famechon | [[Category: Famechon A]] | ||
[[Category: Giglione | [[Category: Giglione C]] | ||
[[Category: Gil | [[Category: Gil P]] | ||
[[Category: Guilloteau | [[Category: Guilloteau J-P]] | ||
[[Category: Mathieu | [[Category: Mathieu M]] | ||
[[Category: Meinnel | [[Category: Meinnel T]] | ||
[[Category: Mikol | [[Category: Mikol V]] | ||
Latest revision as of 07:35, 14 February 2024
Crystal Structure of E.coli Peptide Deformylase Complexed with Antibiotic Actinonin
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