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[[Image:1kod.png|left|200px]]


{{STRUCTURE_1kod| PDB=1kod |  SCENE= }}
==RNA APTAMER COMPLEXED WITH CITRULLINE, NMR==
<StructureSection load='1kod' size='340' side='right'caption='[[1kod]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1kod]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KOD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIR:CITRULLINE'>CIR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kod OCA], [https://pdbe.org/1kod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kod RCSB], [https://www.ebi.ac.uk/pdbsum/1kod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kod ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
In a previous study, an RNA aptamer for the specific recognition of arginine was evolved from a parent sequence that bound citrulline specifically. The two RNAs differ at only 3 positions out of 44. The solution structures of the two aptamers complexed to their cognate amino acids have now been determined by two-dimensional nuclear magnetic resonance spectroscopy. Both aptamers contain two asymmetrical internal loops that are not well ordered in the free RNA but that fold into a compact structure upon ligand binding. Those nucleotides common to both RNAs include a conserved cluster of purine residues, three of which form an uneven plane containing a G:G pair, and two other residues nearly perpendicular to that surface. Two of the three variant nucleotides are stacked on the cluster of purines and form a triple contact to the amino acid side chain, whereas the edge of the third variant nucleotide is capping the binding pocket.


===RNA APTAMER COMPLEXED WITH CITRULLINE, NMR===
Structural basis of ligand discrimination by two related RNA aptamers resolved by NMR spectroscopy.,Yang Y, Kochoyan M, Burgstaller P, Westhof E, Famulok M Science. 1996 May 31;272(5266):1343-7. PMID:8650546<ref>PMID:8650546</ref>


{{ABSTRACT_PUBMED_8650546}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 1kod" style="background-color:#fffaf0;"></div>
[[1kod]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KOD OCA].
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:008650546</ref><references group="xtra"/>
</StructureSection>
[[Category: Burgstaller, P.]]
[[Category: Large Structures]]
[[Category: Famulok, M.]]
[[Category: Burgstaller P]]
[[Category: Kochoyan, M.]]
[[Category: Famulok M]]
[[Category: Westhof, E.]]
[[Category: Kochoyan M]]
[[Category: Yang, Y S.]]
[[Category: Westhof E]]
[[Category: In vitro selected rna]]
[[Category: Yang YS]]
[[Category: Rna]]
[[Category: Rna aptamer]]
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