4h7y: Difference between revisions
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==Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual specificity protein kinase Mps1== | |||
<StructureSection load='4h7y' size='340' side='right'caption='[[4h7y]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4h7y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H7Y FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7y OCA], [https://pdbe.org/4h7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h7y RCSB], [https://www.ebi.ac.uk/pdbsum/4h7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h7y ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> | |||
=== | ==See Also== | ||
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]] | |||
== References == | |||
<references/> | |||
== | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Blundell TL]] | ||
[[Category: | [[Category: Bolanos-Garcia VM]] | ||
[[Category: | [[Category: Chirgadze DY]] | ||
Latest revision as of 11:35, 1 March 2024
Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual specificity protein kinase Mps1
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