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[[Image:1oy0.png|left|200px]]


{{STRUCTURE_1oy0|  PDB=1oy0  |  SCENE=  }}
==The crystal Structure of the First Enzyme of Pantothenate Biosynthetic Pathway, Ketopantoate Hydroxymethyltransferase from Mycobacterium Tuberculosis Shows a Decameric Assembly and Terminal Helix-Swapping==
 
<StructureSection load='1oy0' size='340' side='right'caption='[[1oy0]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
===The crystal Structure of the First Enzyme of Pantothenate Biosynthetic Pathway, Ketopantoate Hydroxymethyltransferase from Mycobacterium Tuberculosis Shows a Decameric Assembly and Terminal Helix-Swapping===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1oy0]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OY0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OY0 FirstGlance]. <br>
{{ABSTRACT_PUBMED_12842039}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oy0 OCA], [https://pdbe.org/1oy0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oy0 RCSB], [https://www.ebi.ac.uk/pdbsum/1oy0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oy0 ProSAT]</span></td></tr>
[[1oy0]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OY0 OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/PANB_MYCTU PANB_MYCTU] Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate.<ref>PMID:12515554</ref>  
<ref group="xtra">PMID:012842039</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Category: 3-methyl-2-oxobutanoate hydroxymethyltransferase]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oy/1oy0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oy0 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Chaudhuri, B N.]]
[[Category: Chaudhuri BN]]
[[Category: Kim, C Y.]]
[[Category: Kim CY]]
[[Category: Park, M S.]]
[[Category: Park MS]]
[[Category: Sawaya, M R.]]
[[Category: Sawaya MR]]
[[Category: TBSGC, TB Structural Genomics Consortium.]]
[[Category: Terwilliger TC]]
[[Category: Terwilliger, T C.]]
[[Category: Waldo GS]]
[[Category: Waldo, G S.]]
[[Category: Yeates TO]]
[[Category: Yeates, T O.]]
[[Category: Domain swapping]]
[[Category: Protein structure initiative]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Tb structural genomics consortium]]
[[Category: Tbsgc]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/1oy0"