4iau: Difference between revisions
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The | ==Atomic resolution structure of Geodin, a beta-gamma crystallin from Geodia cydonium== | ||
<StructureSection load='4iau' size='340' side='right'caption='[[4iau]], [[Resolution|resolution]] 0.99Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4iau]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geodia_cydonium Geodia cydonium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IAU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.99Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iau OCA], [https://pdbe.org/4iau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iau RCSB], [https://www.ebi.ac.uk/pdbsum/4iau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iau ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/O18426_GEOCY O18426_GEOCY] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The betagamma-crystallin superfamily includes highly diverse proteins belonging to all of the kingdoms of life. Based on structural topology, these proteins are considered to be evolutionarily related to the long-lived betagamma-crystallins that constitute the vertebrate eye lens. This study reports the crystallographic structure at 0.99 A resolution of the two-domain betagamma-crystallin (geodin) from the sponge Geodia cydonium. This is the most ancient member of the betagamma-crystallin superfamily in metazoans. The X-ray structure shows that the geodin domains adopt the typical betagamma-crystallin fold with a paired Greek-key motif, thus confirming the hypothesis that the crystallin-type scaffold used in the evolution of bacteria and moulds was recruited very early in metazoans. As a significant new structural feature, the sponge protein possesses a unique interdomain interface made up by pairing between the second motif of the first domain and the first motif of the second domain. The atomic resolution also allowed a detailed analysis of the calcium-binding site of the protein. | |||
A novel interdomain interface in crystallins: structural characterization of the betagamma-crystallin from Geodia cydonium at 0.99 A resolution.,Vergara A, Grassi M, Sica F, Pizzo E, D'Alessio G, Mazzarella L, Merlino A Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):960-7. doi:, 10.1107/S0907444913003569. Epub 2013 May 2. PMID:23695240<ref>PMID:23695240</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4iau" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Crystallin 3D structures|Crystallin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Geodia cydonium]] | |||
[[Category: Large Structures]] | |||
[[Category: Grassi M]] | |||
[[Category: Mazzarella L]] | |||
[[Category: Merlino A]] | |||
[[Category: Sica F]] | |||
[[Category: Vergara A]] | |||
Latest revision as of 06:35, 17 October 2024
Atomic resolution structure of Geodin, a beta-gamma crystallin from Geodia cydonium
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