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[[Image:1pkm.png|left|200px]]


{{STRUCTURE_1pkm|  PDB=1pkm  |  SCENE=  }}
==THE REFINED THREE-DIMENSIONAL STRUCTURE OF CAT MUSCLE (M1) PYRUVATE KINASE, AT A RESOLUTION OF 2.6 ANGSTROMS==
 
<StructureSection load='1pkm' size='340' side='right'caption='[[1pkm]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
===THE REFINED THREE-DIMENSIONAL STRUCTURE OF CAT MUSCLE (M1) PYRUVATE KINASE, AT A RESOLUTION OF 2.6 ANGSTROMS===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1pkm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Felis_catus Felis catus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PKM FirstGlance]. <br>
{{ABSTRACT_PUBMED_15299671}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pkm OCA], [https://pdbe.org/1pkm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pkm RCSB], [https://www.ebi.ac.uk/pdbsum/1pkm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pkm ProSAT]</span></td></tr>
==About this Structure==
</table>
[[1pkm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Felis_catus Felis catus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKM OCA].  
== Function ==
[https://www.uniprot.org/uniprot/KPYM_FELCA KPYM_FELCA] Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pk/1pkm_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pkm ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Pyruvate Kinase|Pyruvate Kinase]]
*[[Pyruvate kinase 3D structures|Pyruvate kinase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:015299671</ref><references group="xtra"/>
[[Category: Felis catus]]
[[Category: Felis catus]]
[[Category: Pyruvate kinase]]
[[Category: Large Structures]]
[[Category: Allen, S C.]]
[[Category: Allen SC]]
[[Category: Muirhead, H.]]
[[Category: Muirhead H]]
[[Category: Kinase]]
[[Category: Pyruvate kinase]]
Retrieved from "https://proteopedia.org/1pkm"