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[[Image:1pq3.png|left|200px]]


{{STRUCTURE_1pq3| PDB=1pq3 | SCENE= }}
==Human Arginase II: Crystal Structure and Physiological Role in Male and Female Sexual Arousal==
<StructureSection load='1pq3' size='340' side='right'caption='[[1pq3]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1pq3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PQ3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=S2C:S-2-(BORONOETHYL)-L-CYSTEINE'>S2C</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pq3 OCA], [https://pdbe.org/1pq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pq3 RCSB], [https://www.ebi.ac.uk/pdbsum/1pq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pq3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ARGI2_HUMAN ARGI2_HUMAN] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pq/1pq3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pq3 ConSurf].
<div style="clear:both"></div>


===Human Arginase II: Crystal Structure and Physiological Role in Male and Female Sexual Arousal===
==See Also==
 
*[[Arginase 3D structures|Arginase 3D structures]]
{{ABSTRACT_PUBMED_12859189}}
__TOC__
 
</StructureSection>
==About this Structure==
[[1pq3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PQ3 OCA].
 
==Reference==
<ref group="xtra">PMID:012859189</ref><references group="xtra"/>
[[Category: Arginase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ash, D E.]]
[[Category: Large Structures]]
[[Category: Cama, E.]]
[[Category: Ash DE]]
[[Category: Christianson, D W.]]
[[Category: Cama E]]
[[Category: Colleluori, D M.]]
[[Category: Christianson DW]]
[[Category: Emig, F A.]]
[[Category: Colleluori DM]]
[[Category: Kim, N N.]]
[[Category: Emig FA]]
[[Category: Kim, S W.]]
[[Category: Kim NN]]
[[Category: Shin, H.]]
[[Category: Kim SW]]
[[Category: Traish, A M.]]
[[Category: Shin H]]
[[Category: Biosynthetic protein]]
[[Category: Traish AM]]
[[Category: Hydrolase]]
Retrieved from "https://proteopedia.org/1pq3"