1p9f: Difference between revisions

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~~[[Image:1p9f.png|left|200px]]~~

~~{{STRUCTURE_1p9f~~| ~~PDB~~=1p9f ~~| SCENE~~= }}

==NMR Structure of Neurokinin B from DYANA==

== Structural highlights ==

<table><tr><td colspan='2'>[[1p9f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P9F FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9f OCA], [https://pdbe.org/1p9f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p9f RCSB], [https://www.ebi.ac.uk/pdbsum/1p9f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p9f ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/TKNK_HUMAN TKNK_HUMAN] Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity).

== Publication Abstract from PubMed ==

Neurokinin B (NKB), a decapeptide of mammalian origin exhibits a variety of biological activities such as regulatory functions in reproduction, pre-eclampsia and neuroprotection in Alzheimer's disease. In order to gain insight into structure-function relationship, three-dimensional structure of NKB has been investigated using CD spectropolarimetry and two-dimensional proton nuclear magnetic resonance (2D 1H-NMR) spectroscopy in aqueous and membrane mimetic solvents. Unambiguous NMR assignments of resonances have been made with the aid of correlation spectroscopy (DQF-COSY and TOCSY) experiments and Nuclear Overhauser Effect Spectroscopy (NOESY) experiments. Distance constraints obtained from the NMR data have been used to generate a family of structures, which have been refined using restrained energy minimization and dynamics. Our data show that a helical structure is induced in NKB, in presence of perdeuterated dodecyl phosphocholine (DPC) micelles, a membrane model system. Further, the conformation adopted by NKB in presence of DPC micelles represents a structural motif typical of neurokinin-3 selective agonists.

~~===NMR Structure~~ of ~~Neurokinin~~ B ~~from DYANA===~~

Three dimensional structure of mammalian tachykinin peptide neurokinin B bound to lipid micelles.,Mantha AK, Chandrashekar IR, Baquer NZ, Cowsik SM J Biomol Struct Dyn. 2004 Oct;22(2):137-48. PMID:15317475<ref>PMID:15317475</ref>

~~{{ABSTRACT_PUBMED_15317475}}~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

==~~About this Structure~~==

~~[[1p9f]] is a 1 chain structure. Full experimental information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=1P9F OCA].~~

== References ==

[[Category: ~~Baquer, N Z.~~]]

[[Category: ~~Chandrashekar, I R.~~]]

__TOC__

[[Category: ~~Cowsik, S M.~~]]

</StructureSection>

[[Category: ~~Mantha, A K.~~]]

[[Category: Homo sapiens]]

[[Category: ~~Neuropeptide~~]]

[[Category: Large Structures]]

[[Category: ~~Protein]]~~

[[Category: Baquer NZ]]

~~[[Category: Structures from dyana~~]]

[[Category: Chandrashekar IR]]

[[Category: Cowsik SM]]

[[Category: Mantha AK]]

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@@ Line 1: / Line 1: @@
-[[Image:1p9f.png|left|200px]]
-{{STRUCTURE_1p9f|  PDB=1p9f  |  SCENE=  }}
+==NMR Structure of Neurokinin B from DYANA==
+<StructureSection load='1p9f' size='340' side='right'caption='[[1p9f]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1p9f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P9F FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9f OCA], [https://pdbe.org/1p9f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p9f RCSB], [https://www.ebi.ac.uk/pdbsum/1p9f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p9f ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TKNK_HUMAN TKNK_HUMAN] Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity).
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Neurokinin B (NKB), a decapeptide of mammalian origin exhibits a variety of biological activities such as regulatory functions in reproduction, pre-eclampsia and neuroprotection in Alzheimer's disease. In order to gain insight into structure-function relationship, three-dimensional structure of NKB has been investigated using CD spectropolarimetry and two-dimensional proton nuclear magnetic resonance (2D 1H-NMR) spectroscopy in aqueous and membrane mimetic solvents. Unambiguous NMR assignments of resonances have been made with the aid of correlation spectroscopy (DQF-COSY and TOCSY) experiments and Nuclear Overhauser Effect Spectroscopy (NOESY) experiments. Distance constraints obtained from the NMR data have been used to generate a family of structures, which have been refined using restrained energy minimization and dynamics. Our data show that a helical structure is induced in NKB, in presence of perdeuterated dodecyl phosphocholine (DPC) micelles, a membrane model system. Further, the conformation adopted by NKB in presence of DPC micelles represents a structural motif typical of neurokinin-3 selective agonists.
-===NMR Structure of Neurokinin B from DYANA===
+Three dimensional structure of mammalian tachykinin peptide neurokinin B bound to lipid micelles.,Mantha AK, Chandrashekar IR, Baquer NZ, Cowsik SM J Biomol Struct Dyn. 2004 Oct;22(2):137-48. PMID:15317475<ref>PMID:15317475</ref>
-{{ABSTRACT_PUBMED_15317475}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 1p9f" style="background-color:#fffaf0;"></div>
-[[1p9f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9F OCA].
+== References ==
-[[Category: Baquer, N Z.]]
+<references/>
-[[Category: Chandrashekar, I R.]]
+__TOC__
-[[Category: Cowsik, S M.]]
+</StructureSection>
-[[Category: Mantha, A K.]]
+[[Category: Homo sapiens]]
-[[Category: Neuropeptide]]
+[[Category: Large Structures]]
-[[Category: Protein]]
+[[Category: Baquer NZ]]
-[[Category: Structures from dyana]]
+[[Category: Chandrashekar IR]]
+[[Category: Cowsik SM]]
+[[Category: Mantha AK]]