Cholesterol esterase: Difference between revisions
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<StructureSection load=' | <StructureSection load='1llf' size='350' side='right' caption='Glycosylated cholesterol esterase dimer complex with bile acid (PDB entry [[1llf]])' scene='52/525136/Cv/1'> | ||
== Function == | |||
'''Cholesterol esterase''' (ChoE) also named '''bile-salt activated lipase''' or '''sterol esterase''' catalyzes the hydrolytic cleavage of cholesterol, other sterol esters and triglycerides.<ref>PMID:11563913</ref> | |||
== Disease == | |||
Deficiency of this enzyme causes Wolman’s disease and cholesteryl ester storage disease. | |||
== Structural highlights == | |||
ChoE <scene name='52/525136/Cv/9'>ligand-binding tunnel is ca. 30 A long</scene> ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}). ChoE has the <scene name='52/525136/Cv/10'>polar catalytic triad Ser-His-Glu</scene> at the opening and <scene name='52/525136/Cv/11'>hydrophobic residues lining the bottom cup</scene>.<ref>PMID:12499539</ref> | |||
==3D structures of cholesterol esterase== | ==3D structures of cholesterol esterase== | ||
[[Cholesterol esterase 3D structures]] | |||
</StructureSection> | |||
== References == | |||
<references/> | |||
[[ | [[Category:Topic Page]] | ||
Latest revision as of 10:17, 12 May 2019
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