4fva: Difference between revisions

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~~[[Image:4fva.png|left|200px]]~~

~~{{STRUCTURE_4fva~~| ~~PDB~~=4fva | ~~SCENE~~= }}

==Crystal structure of truncated Caenorhabditis elegans TDP2==

== Structural highlights ==

<table><tr><td colspan='2'>[[4fva]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FVA OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4FVA FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4fva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fva OCA], [https://pdbe.org/4fva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fva RCSB], [https://www.ebi.ac.uk/pdbsum/4fva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fva ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/TYDP2_CAEEL TYDP2_CAEEL] DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals (By similarity).

==~~=Crystal structure of truncated Caenorhabditis elegans TDP2===~~

==See Also==

*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]

~~{{ABSTRACT_PUBMED_23104058}}~~

__TOC__

</StructureSection>

~~==About this Structure~~==

[[~~4fva~~]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/~~ocashort?id=4FVA OCA].~~

[[Category: Caenorhabditis elegans]]

[[Category: ~~Aihara, H.~~]]

[[Category: Large Structures]]

[[Category: ~~Kurahashi, K.~~]]

[[Category: Aihara H]]

[[Category: ~~Shi,~~ K.]]

[[Category: Kurahashi K]]

[[Category: ~~5'-phosphotyrosyl-dna diesterase]]~~

[[Category: Shi K]]

~~[[Category: Hydrolase~~]]

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@@ Line 1: / Line 1: @@
-[[Image:4fva.png|left|200px]]
-{{STRUCTURE_4fva|  PDB=4fva  |  SCENE=  }}
+==Crystal structure of truncated Caenorhabditis elegans TDP2==
+<StructureSection load='4fva' size='340' side='right'caption='[[4fva]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4fva]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FVA FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fva OCA], [https://pdbe.org/4fva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fva RCSB], [https://www.ebi.ac.uk/pdbsum/4fva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fva ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TYDP2_CAEEL TYDP2_CAEEL] DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals (By similarity).
-===Crystal structure of truncated Caenorhabditis elegans TDP2===
+==See Also==
+*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
-{{ABSTRACT_PUBMED_23104058}}
+__TOC__
+</StructureSection>
-==About this Structure==
-[[4fva]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FVA OCA].
 [[Category: Caenorhabditis elegans]]
-[[Category: Aihara, H.]]
+[[Category: Large Structures]]
-[[Category: Kurahashi, K.]]
+[[Category: Aihara H]]
-[[Category: Shi, K.]]
+[[Category: Kurahashi K]]
-[[Category: 5'-phosphotyrosyl-dna diesterase]]
+[[Category: Shi K]]
-[[Category: Hydrolase]]