1t3p: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(16 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1t3p.gif|left|200px]]<br /><applet load="1t3p" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1t3p, resolution 1.60&Aring;" />
'''Half-sandwich arene ruthenium(II)-enzyme complex'''<br />


==Overview==
==Half-sandwich arene ruthenium(II)-enzyme complex==
<StructureSection load='1t3p' size='340' side='right'caption='[[1t3p]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1t3p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T3P FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RU7:PARA-CYMENE+RUTHENIUM+CHLORIDE'>RU7</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3p OCA], [https://pdbe.org/1t3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t3p RCSB], [https://www.ebi.ac.uk/pdbsum/1t3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t3p ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t3/1t3p_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t3p ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The 1.6 [Angstrom] X-ray crystal structure of [(eta(6)-p-cymene)Ru(lysozyme)Cl(2)], the first of a half-sandwich complex of a protein, shows selective ruthenation of Nepsilon of the imidazole ring of His15.
The 1.6 [Angstrom] X-ray crystal structure of [(eta(6)-p-cymene)Ru(lysozyme)Cl(2)], the first of a half-sandwich complex of a protein, shows selective ruthenation of Nepsilon of the imidazole ring of His15.


==About this Structure==
Half-sandwich arene ruthenium(II)-enzyme complex.,McNae IW, Fishburne K, Habtemariam A, Hunter TM, Melchart M, Wang F, Walkinshaw MD, Sadler PJ Chem Commun (Camb). 2004 Aug 21;(16):1786-7. Epub 2004 Jul 27. PMID:15306883<ref>PMID:15306883</ref>
1T3P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=ACT:'>ACT</scene> and <scene name='pdbligand=RU7:'>RU7</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3P OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Half-sandwich arene ruthenium(II)-enzyme complex., McNae IW, Fishburne K, Habtemariam A, Hunter TM, Melchart M, Wang F, Walkinshaw MD, Sadler PJ, Chem Commun (Camb). 2004 Aug 21;(16):1786-7. Epub 2004 Jul 27. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15306883 15306883]
</div>
<div class="pdbe-citations 1t3p" style="background-color:#fffaf0;"></div>
 
==See Also==
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Lysozyme]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Fishburne K]]
[[Category: Fishburne, K.]]
[[Category: Habtemariam A]]
[[Category: Habtemariam, A.]]
[[Category: Hunter TM]]
[[Category: Hunter, T M.]]
[[Category: McNae IW]]
[[Category: McNae, I W.]]
[[Category: Melchart M]]
[[Category: Melchart, M.]]
[[Category: Sadler PJ]]
[[Category: Sadler, P J.]]
[[Category: Walkinshaw MD]]
[[Category: Walkinshaw, M D.]]
[[Category: Wang F]]
[[Category: Wang, F.]]
[[Category: ACT]]
[[Category: CL]]
[[Category: NA]]
[[Category: RU7]]
[[Category: ruthenium]]
[[Category: tetragonal lysozyme]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:09:32 2008''
Retrieved from "https://proteopedia.org/1t3p"