4eb5: Difference between revisions
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==A. fulgidus IscS-IscU complex structure== | |||
<StructureSection load='4eb5' size='340' side='right'caption='[[4eb5]], [[Resolution|resolution]] 2.53Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4eb5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_DSM_4304 Archaeoglobus fulgidus DSM 4304]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EB5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.53Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eb5 OCA], [https://pdbe.org/4eb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eb5 RCSB], [https://www.ebi.ac.uk/pdbsum/4eb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eb5 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ISCS2_ARCFU ISCS2_ARCFU] Catalyzes the removal of elemental sulfur from cysteine to produce alanine (By similarity). | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The center of attention: IscS cysteine desulfurases and IscU scaffolds are involved in biological iron-sulfur cluster assembly. The X-ray structure of an anaerobically produced, mutated (Fe(2) S(2) -(IscS-IscU(D35A) ))(2) complex reveals a cluster coordinated by three IscU cysteines and the IscS active cysteine. In air-exposed crystals the cluster is oxidized to an Fe(2) S-S center; D35 is essential for complex dissociation. | |||
(IscS-IscU)(2) Complex Structures Provide Insights into Fe(2) S(2) Biogenesis and Transfer.,Marinoni EN, de Oliveira JS, Nicolet Y, Raulfs EC, Amara P, Dean DR, Fontecilla-Camps JC Angew Chem Int Ed Engl. 2012 Apr 18. doi: 10.1002/anie.201201708. PMID:22511353<ref>PMID:22511353</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4eb5" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
== | __TOC__ | ||
< | </StructureSection> | ||
[[Category: Archaeoglobus fulgidus | [[Category: Archaeoglobus fulgidus DSM 4304]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Amara | [[Category: Amara P]] | ||
[[Category: Dean | [[Category: Dean DR]] | ||
[[Category: Fontecilla-Camps | [[Category: Fontecilla-Camps JC]] | ||
[[Category: Marinoni | [[Category: Marinoni EN]] | ||
[[Category: Nicolet | [[Category: Nicolet Y]] | ||
[[Category: Raulfs EC]] | |||
[[Category: Raulfs | [[Category: De Oliveira JS]] | ||
[[Category: | |||
Latest revision as of 10:50, 13 August 2026
A. fulgidus IscS-IscU complex structure
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