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[[Image:1qaq.png|left|200px]]


{{STRUCTURE_1qaq|  PDB=1qaq  |  SCENE=  }}
==THE STRUCTURE OF THE RRNA METHYLTRANSFERASE ERMC': IMPLICATIONS FOR THE REACTION MECHANISM==
 
<StructureSection load='1qaq' size='340' side='right'caption='[[1qaq]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
===THE STRUCTURE OF THE RRNA METHYLTRANSFERASE ERMC': IMPLICATIONS FOR THE REACTION MECHANISM===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1qaq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QAQ FirstGlance]. <br>
{{ABSTRACT_PUBMED_10366505}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qaq OCA], [https://pdbe.org/1qaq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qaq RCSB], [https://www.ebi.ac.uk/pdbsum/1qaq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qaq ProSAT]</span></td></tr>
[[1qaq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QAQ OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/ERM_BACIU ERM_BACIU] This protein produces a dimethylation of the adenine residue at position 2085 in 23S rRNA, resulting in reduced affinity between ribosomes and macrolide-lincosamide-streptogramin B antibiotics.<ref>PMID:12907737</ref> <ref>PMID:12946350</ref>  
<ref group="xtra">PMID:010366505</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qa/1qaq_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qaq ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Abad-Zapatero, C.]]
[[Category: Large Structures]]
[[Category: Kavanaugh, T. J.]]
[[Category: Abad-Zapatero C]]
[[Category: Schluckebier, G.]]
[[Category: Kavanaugh TJ]]
[[Category: Stewart, K. D.]]
[[Category: Schluckebier G]]
[[Category: Zhong, P.]]
[[Category: Stewart KD]]
[[Category: Binary complex with adenosyl-ornithine]]
[[Category: Zhong P]]
[[Category: Transferase]]
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