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[[Image:1qpr.png|left|200px]]


{{STRUCTURE_1qpr|  PDB=1qpr  |  SCENE=  }}
==QUINOLINATE PHOSPHORIBOSYLTRANSFERASE (QAPRTASE) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH PHTHALATE AND PRPCP==
 
<StructureSection load='1qpr' size='340' side='right'caption='[[1qpr]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
===QUINOLINATE PHOSPHORIBOSYLTRANSFERASE (QAPRTASE) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH PHTHALATE AND PRPCP===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1qpr]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QPR FirstGlance]. <br>
{{ABSTRACT_PUBMED_9862811}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PHT:PHTHALIC+ACID'>PHT</scene>, <scene name='pdbligand=PPC:5-PHOSPHORIBOSYL-1-(BETA-METHYLENE)+PYROPHOSPHATE'>PPC</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qpr OCA], [https://pdbe.org/1qpr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qpr RCSB], [https://www.ebi.ac.uk/pdbsum/1qpr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qpr ProSAT], [https://www.topsan.org/Proteins/TBSGC/1qpr TOPSAN]</span></td></tr>
[[1qpr]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QPR OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/NADC_MYCTU NADC_MYCTU] Involved in the catabolism of quinolinic acid (QA) (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qp/1qpr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qpr ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Phosphoribosyltransferase|Phosphoribosyltransferase]]
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:009862811</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis h37rv]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Grubmeyer, C.]]
[[Category: Grubmeyer C]]
[[Category: Sacchettini, J C.]]
[[Category: Sacchettini JC]]
[[Category: Sharma, V.]]
[[Category: Sharma V]]
[[Category: TBSGC, TB Structural Genomics Consortium.]]
[[Category: De novo nad biosynthesis]]
[[Category: Phosphoribosyltransferase]]
[[Category: Protein structure initiative]]
[[Category: Prpp]]
[[Category: Prtase]]
[[Category: Psi]]
[[Category: Quinolinic acid]]
[[Category: Structural genomic]]
[[Category: Tb structural genomics consortium]]
[[Category: Tbsgc]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/1qpr"