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[[Image:1qd1.png|left|200px]]


{{STRUCTURE_1qd1|  PDB=1qd1  |  SCENE=  }}
==THE CRYSTAL STRUCTURE OF THE FORMIMINOTRANSFERASE DOMAIN OF FORMIMINOTRANSFERASE-CYCLODEAMINASE.==
 
<StructureSection load='1qd1' size='340' side='right'caption='[[1qd1]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
===THE CRYSTAL STRUCTURE OF THE FORMIMINOTRANSFERASE DOMAIN OF FORMIMINOTRANSFERASE-CYCLODEAMINASE.===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1qd1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QD1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QD1 FirstGlance]. <br>
{{ABSTRACT_PUBMED_10673422}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FON:N-{[4-({[(6R)-2-AMINO-5-FORMYL-4-OXO-1,4,5,6,7,8-HEXAHYDROPTERIDIN-6-YL]METHYL}AMINO)PHENYL]CARBONYL}-L-GLUTAMIC+ACID'>FON</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qd1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qd1 OCA], [https://pdbe.org/1qd1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qd1 RCSB], [https://www.ebi.ac.uk/pdbsum/1qd1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qd1 ProSAT]</span></td></tr>
[[1qd1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QD1 OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/FTCD_PIG FTCD_PIG] Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.  Binds and promotes bundling of vimentin filaments originating from the Golgi (By similarity).
<ref group="xtra">PMID:010673422</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Category: Glutamate formimidoyltransferase]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qd/1qd1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qd1 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
[[Category: Kohls, D.]]
[[Category: Kohls D]]
[[Category: MacKenzie, R E.]]
[[Category: MacKenzie RE]]
[[Category: Purisima, E.]]
[[Category: Purisima E]]
[[Category: Sulea, T.]]
[[Category: Sulea T]]
[[Category: Vrielink, A.]]
[[Category: Vrielink A]]
[[Category: Alpha-beta-beta-alpha sandwich]]
[[Category: Electrostatically charged substrate tunnel]]
[[Category: Functional dimer]]
[[Category: Transferase]]

Latest revision as of 08:15, 14 February 2024

THE CRYSTAL STRUCTURE OF THE FORMIMINOTRANSFERASE DOMAIN OF FORMIMINOTRANSFERASE-CYCLODEAMINASE.

1qd1, resolution 1.70Å

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