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[[Image:1uhp.png|left|200px]]


{{STRUCTURE_1uhp|  PDB=1uhp  |  SCENE=  }}
==Solution structure of RSGI RUH-005, a PDZ domain in human cDNA, KIAA1095==
 
<StructureSection load='1uhp' size='340' side='right'caption='[[1uhp]]' scene=''>
===Solution structure of RSGI RUH-005, a PDZ domain in human cDNA, KIAA1095===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1uhp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UHP FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uhp OCA], [https://pdbe.org/1uhp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uhp RCSB], [https://www.ebi.ac.uk/pdbsum/1uhp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uhp ProSAT], [https://www.topsan.org/Proteins/RSGI/1uhp TOPSAN]</span></td></tr>
[[1uhp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UHP OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/PZRN3_HUMAN PZRN3_HUMAN] E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uh/1uhp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uhp ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hamada, T.]]
[[Category: Large Structures]]
[[Category: Hirota, H.]]
[[Category: Hamada T]]
[[Category: Muto, Y.]]
[[Category: Hirota H]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Muto Y]]
[[Category: Yokoyama, S.]]
[[Category: Yokoyama S]]
[[Category: Pdz domain]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Semaphorin cytoplasmic domain associated protein]]
[[Category: Structural genomic]]
[[Category: Unknown function]]
Retrieved from "https://proteopedia.org/1uhp"