1x6b: Difference between revisions

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[[Image:1x6b.png|left|200px]]


{{STRUCTURE_1x6b| PDB=1x6b | SCENE= }}
==Solution structures of the SH3 domain of human rho guanine exchange factor (GEF) 16==
<StructureSection load='1x6b' size='340' side='right'caption='[[1x6b]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1x6b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X6B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X6B FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x6b OCA], [https://pdbe.org/1x6b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x6b RCSB], [https://www.ebi.ac.uk/pdbsum/1x6b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x6b ProSAT], [https://www.topsan.org/Proteins/RSGI/1x6b TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ARHGG_HUMAN ARHGG_HUMAN] Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.<ref>PMID:20679435</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x6/1x6b_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x6b ConSurf].
<div style="clear:both"></div>


===Solution structures of the SH3 domain of human rho guanine exchange factor (GEF) 16===
==See Also==
 
*[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]]
 
== References ==
==About this Structure==
<references/>
[[1x6b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X6B OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Inoue, M.]]
[[Category: Large Structures]]
[[Category: Kigawa, T.]]
[[Category: Inoue M]]
[[Category: Koshiba, S.]]
[[Category: Kigawa T]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Koshiba S]]
[[Category: Saito, K.]]
[[Category: Saito K]]
[[Category: Sato, M.]]
[[Category: Sato M]]
[[Category: Yokoyama, S.]]
[[Category: Yokoyama S]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Neuroblastoma]]
[[Category: Nppsfa]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Sh3 domain]]
[[Category: Signaling protein]]
[[Category: Structural genomic]]
Retrieved from "https://proteopedia.org/1x6b"