1t56: Difference between revisions
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==Crystal structure of TetR family repressor M. tuberculosis EthR== | |||
<StructureSection load='1t56' size='340' side='right'caption='[[1t56]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1t56]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T56 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t56 OCA], [https://pdbe.org/1t56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t56 RCSB], [https://www.ebi.ac.uk/pdbsum/1t56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t56 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t5/1t56_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t56 ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
[[ | </StructureSection> | ||
[[Category: Large Structures]] | |||
== | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
< | [[Category: Besra GS]] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Cocklin SL]] | ||
[[Category: Besra | [[Category: Corsino PE]] | ||
[[Category: Cocklin | [[Category: Daniels IR]] | ||
[[Category: Corsino | [[Category: Dover LG]] | ||
[[Category: Daniels | [[Category: Futterer K]] | ||
[[Category: Dover | [[Category: Tatituri V]] | ||
[[Category: Futterer | |||
[[Category: Tatituri | |||
Latest revision as of 08:36, 14 February 2024
Crystal structure of TetR family repressor M. tuberculosis EthR
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