1tt9: Difference between revisions
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==Structure of the bifunctional and Golgi associated formiminotransferase cyclodeaminase octamer== | |||
<StructureSection load='1tt9' size='340' side='right'caption='[[1tt9]], [[Resolution|resolution]] 3.42Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1tt9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TT9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TT9 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.42Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tt9 OCA], [https://pdbe.org/1tt9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tt9 RCSB], [https://www.ebi.ac.uk/pdbsum/1tt9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tt9 ProSAT]</span></td></tr> | ||
[[1tt9]] is a 4 chain structure with sequence from [ | </table> | ||
== Function == | |||
== | [https://www.uniprot.org/uniprot/FTCD_RAT FTCD_RAT] Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity).<ref>PMID:12160147</ref> Binds and promotes bundling of vimentin filaments originating from the Golgi.<ref>PMID:12160147</ref> | ||
< | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tt/1tt9_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tt9 ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Chen | [[Category: Chen DH]] | ||
[[Category: Chiu | [[Category: Chiu W]] | ||
[[Category: Ludtke | [[Category: Ludtke SJ]] | ||
[[Category: Mao | [[Category: Mao Y]] | ||
[[Category: Quiocho | [[Category: Quiocho FA]] | ||
[[Category: Vyas | [[Category: Vyas MN]] | ||
[[Category: Vyas | [[Category: Vyas NK]] | ||
Latest revision as of 08:41, 14 February 2024
Structure of the bifunctional and Golgi associated formiminotransferase cyclodeaminase octamer
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