1txd: Difference between revisions

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[[Image:1txd.png|left|200px]]


{{STRUCTURE_1txd| PDB=1txd | SCENE= }}
==Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF==
<StructureSection load='1txd' size='340' side='right'caption='[[1txd]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1txd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TXD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1txd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1txd OCA], [https://pdbe.org/1txd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1txd RCSB], [https://www.ebi.ac.uk/pdbsum/1txd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1txd ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ARHGC_HUMAN ARHGC_HUMAN] Note=A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with MLL.
== Function ==
[https://www.uniprot.org/uniprot/ARHGC_HUMAN ARHGC_HUMAN] May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.<ref>PMID:11094164</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tx/1txd_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1txd ConSurf].
<div style="clear:both"></div>


===Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF===
==See Also==
 
*[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]]
{{ABSTRACT_PUBMED_15331592}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[1txd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXD OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:015331592</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Gao, G.]]
[[Category: Large Structures]]
[[Category: Kristelly, R.]]
[[Category: Gao G]]
[[Category: Tesmer, J J.]]
[[Category: Kristelly R]]
[[Category: Signaling protein]]
[[Category: Tesmer JJ]]
Retrieved from "https://proteopedia.org/1txd"