1svs: Difference between revisions

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[[Image:1svs.png|left|200px]]


{{STRUCTURE_1svs|  PDB=1svs  |  SCENE=  }}
==Structure of the K180P mutant of Gi alpha subunit bound to GppNHp.==
 
<StructureSection load='1svs' size='340' side='right'caption='[[1svs]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
===Structure of the K180P mutant of Gi alpha subunit bound to GppNHp.===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1svs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SVS FirstGlance]. <br>
{{ABSTRACT_PUBMED_15128951}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1svs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1svs OCA], [https://pdbe.org/1svs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1svs RCSB], [https://www.ebi.ac.uk/pdbsum/1svs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1svs ProSAT]</span></td></tr>
[[1svs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SVS OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>  
<ref group="xtra">PMID:015128951</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Category: Heterotrimeric G-protein GTPase]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sv/1svs_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1svs ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Du, X.]]
[[Category: Du X]]
[[Category: Li, P.]]
[[Category: Li P]]
[[Category: Ross, E M.]]
[[Category: Ross EM]]
[[Category: Sprang, S R.]]
[[Category: Sprang SR]]
[[Category: Thomas, C J.]]
[[Category: Thomas CJ]]
[[Category: Wang, Y.]]
[[Category: Wang Y]]
[[Category: Gi alpha subunit]]
[[Category: Hydrolase]]
[[Category: K180p mutation]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/1svs"