1w61: Difference between revisions

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[[Image:1w61.png|left|200px]]


{{STRUCTURE_1w61|  PDB=1w61  |  SCENE= }}
==proline racemase in complex with 2 molecules of pyrrole-2-carboxylic acid (holo form)==
 
<StructureSection load='1w61' size='340' side='right'caption='[[1w61]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
===PROLINE RACEMASE IN COMPLEX WITH 2 MOLECULES OF PYRROLE-2-CARBOXYLIC ACID (HOLO FORM)===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1w61]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W61 FirstGlance]. <br>
{{ABSTRACT_PUBMED_16446443}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PYC:PYRROLE-2-CARBOXYLATE'>PYC</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w61 OCA], [https://pdbe.org/1w61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w61 RCSB], [https://www.ebi.ac.uk/pdbsum/1w61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w61 ProSAT]</span></td></tr>
[[1w61]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W61 OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/PRCMA_TRYCC PRCMA_TRYCC] Catalyzes the interconversion of L- and D-proline. Secreted isoform 1 contributes to parasite immune evasion by acting as a B-cell mitogen. Probably involved in parasite differentiation and infectivity.<ref>PMID:10932226</ref> <ref>PMID:16164548</ref> <ref>PMID:16446443</ref>
<ref group="xtra">PMID:016446443</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Category: Proline racemase]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w6/1w61_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w61 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Trypanosoma cruzi]]
[[Category: Trypanosoma cruzi]]
[[Category: Alzari, P.]]
[[Category: Alzari P]]
[[Category: Buschiazzo, A.]]
[[Category: Buschiazzo A]]
[[Category: Acid/base catalysis]]
[[Category: Alpha/beta domain]]
[[Category: B-cell mitogen]]
[[Category: Homodimer]]
[[Category: Racemase]]
[[Category: Racemase pyridoxal phosphate-independent]]
[[Category: Stereo inversion]]
Retrieved from "https://proteopedia.org/1w61"