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[[Image:1yvf.png|left|200px]]


{{STRUCTURE_1yvf|  PDB=1yvf  |  SCENE=  }}
==Hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00729145==
 
<StructureSection load='1yvf' size='340' side='right'caption='[[1yvf]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
===Hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00729145===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1yvf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YVF FirstGlance]. <br>
{{ABSTRACT_PUBMED_15863301}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PH7:(2Z)-2-(BENZOYLAMINO)-3-[4-(2-BROMOPHENOXY)PHENYL]-2-PROPENOIC+ACID'>PH7</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yvf OCA], [https://pdbe.org/1yvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yvf RCSB], [https://www.ebi.ac.uk/pdbsum/1yvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yvf ProSAT]</span></td></tr>
[[1yvf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVF OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/O93077_9HEPC O93077_9HEPC]  
<ref group="xtra">PMID:015863301</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Category: Hepatitis c virus]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: RNA-directed RNA polymerase]]
Check<jmol>
[[Category: Anstadt, R A.]]
  <jmolCheckbox>
[[Category: Finzel, B C.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yv/1yvf_consurf.spt"</scriptWhenChecked>
[[Category: Greene, M L.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Gross, R J.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Harris, M S.]]
  </jmolCheckbox>
[[Category: Kilkuskie, R E.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yvf ConSurf].
[[Category: Kopta, L A.]]
<div style="clear:both"></div>
[[Category: Mitchell, M A.]]
__TOC__
[[Category: Nugent, R A.]]
</StructureSection>
[[Category: Pfefferkorn, J A.]]
[[Category: Hepacivirus C]]
[[Category: Schwende, F J.]]
[[Category: Large Structures]]
[[Category: Shelly, J A.]]
[[Category: Anstadt RA]]
[[Category: Wells, P A.]]
[[Category: Finzel BC]]
[[Category: Finger]]
[[Category: Greene ML]]
[[Category: Hcv]]
[[Category: Gross RJ]]
[[Category: Ns5b]]
[[Category: Harris MS]]
[[Category: Palm]]
[[Category: Kilkuskie RE]]
[[Category: Polymerase]]
[[Category: Kopta LA]]
[[Category: Thumb]]
[[Category: Mitchell MA]]
[[Category: Transferase]]
[[Category: Nugent RA]]
[[Category: Pfefferkorn JA]]
[[Category: Schwende FJ]]
[[Category: Shelly JA]]
[[Category: Wells PA]]

Latest revision as of 09:00, 14 February 2024

Hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00729145

1yvf, resolution 2.50Å

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