2bbz: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2bbz.png|left|200px]]


{{STRUCTURE_2bbz|  PDB=2bbz  |  SCENE=  }}
==Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition==
 
<StructureSection load='2bbz' size='340' side='right'caption='[[2bbz]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
===Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2bbz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Molluscum_contagiosum_virus_subtype_1 Molluscum contagiosum virus subtype 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BBZ FirstGlance]. <br>
{{ABSTRACT_PUBMED_16364918}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbz OCA], [https://pdbe.org/2bbz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bbz RCSB], [https://www.ebi.ac.uk/pdbsum/2bbz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bbz ProSAT]</span></td></tr>
==About this Structure==
</table>
[[2bbz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Molluscum_contagiosum_virus_subtype_1 Molluscum contagiosum virus subtype 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBZ OCA].  
== Function ==
 
[https://www.uniprot.org/uniprot/CFLA_MCV1 CFLA_MCV1] Inhibits TNFRSF1A, TNFRSF6 and TNFRSF12 induced apoptosis. May interfere with caspase-8 recruitment and activation at the death-inducing signaling complex (DISC). May lead to higher virus production and contribute to virus persistence and oncogenicity.<ref>PMID:9087414</ref> <ref>PMID:9037025</ref>
==Reference==
== Evolutionary Conservation ==
<ref group="xtra">PMID:016364918</ref><references group="xtra"/>
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bb/2bbz_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bbz ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Molluscum contagiosum virus subtype 1]]
[[Category: Molluscum contagiosum virus subtype 1]]
[[Category: Ahmed, M.]]
[[Category: Ahmed M]]
[[Category: Lenardo, M J.]]
[[Category: Lenardo MJ]]
[[Category: Wan, F.]]
[[Category: Wan F]]
[[Category: Wang, L.]]
[[Category: Wang L]]
[[Category: Wu, H.]]
[[Category: Wu H]]
[[Category: Yang, J K.]]
[[Category: Yang JK]]
[[Category: Zheng, L.]]
[[Category: Zheng L]]
[[Category: Death effector domain]]
[[Category: Viral protein]]
Retrieved from "https://proteopedia.org/2bbz"