2eq4: Difference between revisions
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==Solution structure of the 11th C2H2 type zinc finger domain of Zinc finger protein 224== | |||
<StructureSection load='2eq4' size='340' side='right'caption='[[2eq4]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2eq4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EQ4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
== | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[2eq4]] is a 1 chain structure with sequence from [ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eq4 OCA], [https://pdbe.org/2eq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eq4 RCSB], [https://www.ebi.ac.uk/pdbsum/2eq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eq4 ProSAT], [https://www.topsan.org/Proteins/RSGI/2eq4 TOPSAN]</span></td></tr> | ||
</table> | |||
== | == Function == | ||
[https://www.uniprot.org/uniprot/ZN224_HUMAN ZN224_HUMAN] May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.<ref>PMID:20587513</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eq/2eq4_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eq4 ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Inoue | [[Category: Large Structures]] | ||
[[Category: Kigawa | [[Category: Inoue M]] | ||
[[Category: Masuda | [[Category: Kigawa T]] | ||
[[Category: Muto | [[Category: Masuda K]] | ||
[[Category: Muto Y]] | |||
[[Category: Shirouzu | [[Category: Shirouzu M]] | ||
[[Category: Suzuki | [[Category: Suzuki S]] | ||
[[Category: Terada | [[Category: Terada T]] | ||
[[Category: Yokoyama | [[Category: Yokoyama S]] | ||
Latest revision as of 18:54, 29 May 2024
Solution structure of the 11th C2H2 type zinc finger domain of Zinc finger protein 224
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