2d1x: Difference between revisions
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==The crystal structure of the cortactin-SH3 domain and AMAP1-peptide complex== | |||
<StructureSection load='2d1x' size='340' side='right'caption='[[2d1x]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2d1x]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D1X FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d1x OCA], [https://pdbe.org/2d1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d1x RCSB], [https://www.ebi.ac.uk/pdbsum/2d1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d1x ProSAT]</span></td></tr> | ||
[[2d1x]] is a 6 chain structure with sequence from [ | </table> | ||
== Function == | |||
== | [https://www.uniprot.org/uniprot/SRC8_HUMAN SRC8_HUMAN] Contributes to the organization of the actin cytoskeleton and cell structure. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.<ref>PMID:21296879</ref> <ref>PMID:16636290</ref> | ||
< | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d1/2d1x_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d1x ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Agatsuma | [[Category: Large Structures]] | ||
[[Category: Akagi | [[Category: Agatsuma T]] | ||
[[Category: Hashimoto | [[Category: Akagi K]] | ||
[[Category: Hashimoto | [[Category: Hashimoto A]] | ||
[[Category: Hirose | [[Category: Hashimoto S]] | ||
[[Category: Hosaka | [[Category: Hirose M]] | ||
[[Category: Ikegami | [[Category: Hosaka H]] | ||
[[Category: Kobayashi | [[Category: Ikegami T]] | ||
[[Category: Morishige | [[Category: Kobayashi H]] | ||
[[Category: Nakagawa | [[Category: Morishige M]] | ||
[[Category: Nakano | [[Category: Nakagawa A]] | ||
[[Category: Ogawa | [[Category: Nakano H]] | ||
[[Category: Okada | [[Category: Ogawa E]] | ||
[[Category: Oneyama | [[Category: Okada M]] | ||
[[Category: Sabe | [[Category: Oneyama C]] | ||
[[Category: Wada | [[Category: Sabe H]] | ||
[[Category: Yamada | [[Category: Wada H]] | ||
[[Category: Yamada A]] | |||
