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[[Image:2b6f.png|left|200px]]


{{STRUCTURE_2b6f|  PDB=2b6f  |  SCENE=  }}
==Solution structure of human sulfiredoxin (SRX)==
 
<StructureSection load='2b6f' size='340' side='right'caption='[[2b6f]]' scene=''>
===Solution structure of human sulfiredoxin (SRX)===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2b6f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B6F FirstGlance]. <br>
{{ABSTRACT_PUBMED_17176052}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b6f OCA], [https://pdbe.org/2b6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b6f RCSB], [https://www.ebi.ac.uk/pdbsum/2b6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b6f ProSAT]</span></td></tr>
[[2b6f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B6F OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/SRXN1_HUMAN SRXN1_HUMAN] Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.<ref>PMID:15448164</ref> <ref>PMID:15590625</ref>
<ref group="xtra">PMID:017176052</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b6/2b6f_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b6f ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ferretti, J A.]]
[[Category: Large Structures]]
[[Category: Gruschus, J M.]]
[[Category: Ferretti JA]]
[[Category: Lee, D Y.]]
[[Category: Gruschus JM]]
[[Category: Rhee, S G.]]
[[Category: Lee D-Y]]
[[Category: Oxidoreductase]]
[[Category: Rhee SG]]
[[Category: Parb domain fold]]
Retrieved from "https://proteopedia.org/2b6f"