2cua: Difference between revisions

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[[Image:2cua.png|left|200px]]


{{STRUCTURE_2cua| PDB=2cua | SCENE= }}
==THE CUA DOMAIN OF CYTOCHROME BA3 FROM THERMUS THERMOPHILUS==
<StructureSection load='2cua' size='340' side='right'caption='[[2cua]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2cua]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CUA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CUA:DINUCLEAR+COPPER+ION'>CUA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cua OCA], [https://pdbe.org/2cua PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cua RCSB], [https://www.ebi.ac.uk/pdbsum/2cua PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cua ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/COX2_THETH COX2_THETH] Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cu/2cua_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cua ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The structure of the CuA-containing, extracellular domain of Thermus thermophilus ba3-type cytochrome c oxidase has been determined to 1.6 A resolution using multiple X-ray wavelength anomalous dispersion (MAD). The Cu2S2 cluster forms a planar rhombus with a copper-copper distance of 2.51 +/- 0.03 A. X-ray absorption fine-structure (EXAFS) studies show that this distance is unchanged by crystallization. The CuA center is asymmetrical; one copper is tetrahedrally coordinated to two bridging cysteine thiolates, one histidine nitrogen and one methionine sulfur, while the other is trigonally coordinated by the two cysteine thiolates and a histidine nitrogen. Combined sequence-structure alignment of amino acid sequences reveals conserved interactions between cytochrome c oxidase subunits I and II.


===THE CUA DOMAIN OF CYTOCHROME BA3 FROM THERMUS THERMOPHILUS===
The CuA domain of Thermus thermophilus ba3-type cytochrome c oxidase at 1.6 A resolution.,Williams PA, Blackburn NJ, Sanders D, Bellamy H, Stura EA, Fee JA, McRee DE Nat Struct Biol. 1999 Jun;6(6):509-16. PMID:10360350<ref>PMID:10360350</ref>


{{ABSTRACT_PUBMED_10360350}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 2cua" style="background-color:#fffaf0;"></div>
[[2cua]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUA OCA].
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:010360350</ref><references group="xtra"/>
</StructureSection>
[[Category: Cytochrome-c oxidase]]
[[Category: Large Structures]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
[[Category: Bellamy, H.]]
[[Category: Bellamy H]]
[[Category: Blackburn, N J.]]
[[Category: Blackburn NJ]]
[[Category: Fee, J A.]]
[[Category: Fee JA]]
[[Category: Mcree, D E.]]
[[Category: Mcree DE]]
[[Category: Sanders, D.]]
[[Category: Sanders D]]
[[Category: Stura, E A.]]
[[Category: Stura EA]]
[[Category: Williams, P A.]]
[[Category: Williams PA]]
[[Category: Cua center]]
[[Category: Electron transport]]

Latest revision as of 07:52, 13 August 2026

THE CUA DOMAIN OF CYTOCHROME BA3 FROM THERMUS THERMOPHILUS

2cua, resolution 1.60Å

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