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[[Image:2bkw.png|left|200px]]


{{STRUCTURE_2bkw| PDB=2bkw | SCENE= }}
==Yeast alanine:glyoxylate aminotransferase YFL030w==
<StructureSection load='2bkw' size='340' side='right'caption='[[2bkw]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2bkw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BKW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLV:GLYOXYLIC+ACID'>GLV</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bkw OCA], [https://pdbe.org/2bkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bkw RCSB], [https://www.ebi.ac.uk/pdbsum/2bkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bkw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AGX1_YEAST AGX1_YEAST] Has alanine:glyoxylate aminotransferase activity.<ref>PMID:3933486</ref> <ref>PMID:16226833</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bk/2bkw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bkw ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We have determined the three-dimensional crystal structure of the protein encoded by the open reading frame YFL030w from Saccharomyces cerevisiae to a resolution of 2.6 A using single wavelength anomalous diffraction. YFL030w is a 385 amino-acid protein with sequence similarity to the aminotransferase family. The structure of the protein reveals a homodimer adopting the fold-type I of pyridoxal 5'-phosphate (PLP)-dependent aminotransferases. The PLP co-factor is covalently bound to the active site in the crystal structure. The protein shows close structural resemblance with the human alanine:glyoxylate aminotransferase (EC 2.6.1.44), an enzyme involved in the hereditary kidney stone disease primary hyperoxaluria type 1. In this paper we show that YFL030w codes for an alanine:glyoxylate aminotransferase, highly specific for its amino donor and acceptor substrates.


===YEAST ALANINE:GLYOXYLATE AMINOTRANSFERASE YFL030W===
Crystal structure and confirmation of the alanine:glyoxylate aminotransferase activity of the YFL030w yeast protein.,Meyer P, Liger D, Leulliot N, Quevillon-Cheruel S, Zhou CZ, Borel F, Ferrer JL, Poupon A, Janin J, van Tilbeurgh H Biochimie. 2005 Dec;87(12):1041-7. Epub 2005 Oct 5. PMID:16226833<ref>PMID:16226833</ref>


{{ABSTRACT_PUBMED_16226833}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 2bkw" style="background-color:#fffaf0;"></div>
[[2bkw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BKW OCA].
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:016226833</ref><references group="xtra"/>
</StructureSection>
[[Category: Alanine--glyoxylate transaminase]]
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Borel, F.]]
[[Category: Borel F]]
[[Category: Ferrer, J L.]]
[[Category: Ferrer JL]]
[[Category: Janin, J.]]
[[Category: Janin J]]
[[Category: Leulliot, N.]]
[[Category: Leulliot N]]
[[Category: Liger, D.]]
[[Category: Liger D]]
[[Category: Meyer, P.]]
[[Category: Meyer P]]
[[Category: Poupon, A.]]
[[Category: Poupon A]]
[[Category: Quevillon-Cheruel, S.]]
[[Category: Quevillon-Cheruel S]]
[[Category: Tilbeurgh, H Van.]]
[[Category: Zhou CZ]]
[[Category: Zhou, C Z.]]
[[Category: Van Tilbeurgh H]]
[[Category: Analine-glyoxylate aminotransferase]]
[[Category: Glycolate pathway]]
[[Category: Pyridoxal-5-phosphate]]
[[Category: Sad]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/2bkw"