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[[Image:2crn.png|left|200px]]


{{STRUCTURE_2crn|  PDB=2crn  |  SCENE=  }}
==Solution structure of the UBA domain of human UBASH3A protein==
 
<StructureSection load='2crn' size='340' side='right'caption='[[2crn]]' scene=''>
===Solution structure of the UBA domain of human UBASH3A protein===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2crn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CRN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CRN FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2crn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2crn OCA], [https://pdbe.org/2crn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2crn RCSB], [https://www.ebi.ac.uk/pdbsum/2crn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2crn ProSAT], [https://www.topsan.org/Proteins/RSGI/2crn TOPSAN]</span></td></tr>
[[2crn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CRN OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/UBS3A_HUMAN UBS3A_HUMAN] Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.<ref>PMID:15159412</ref> <ref>PMID:17382318</ref> <ref>PMID:18189269</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cr/2crn_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2crn ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hayashi, F.]]
[[Category: Large Structures]]
[[Category: Izumi, K.]]
[[Category: Hayashi F]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Izumi K]]
[[Category: Yokoyama, S.]]
[[Category: Yokoyama S]]
[[Category: Yoshida, M.]]
[[Category: Yoshida M]]
[[Category: Compact three-helix bundle]]
[[Category: Immune system]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
Retrieved from "https://proteopedia.org/2crn"