2b18: Difference between revisions

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[[Image:2b18.png|left|200px]]


{{STRUCTURE_2b18|  PDB=2b18  |  SCENE=  }}
==N-terminal GAF domain of transcriptional pleiotropic repressor CodY.==
 
<StructureSection load='2b18' size='340' side='right'caption='[[2b18]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
===N-terminal GAF domain of transcriptional pleiotropic repressor CodY.===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2b18]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B18 FirstGlance]. <br>
{{ABSTRACT_PUBMED_16488888}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ILE:ISOLEUCINE'>ILE</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b18 OCA], [https://pdbe.org/2b18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b18 RCSB], [https://www.ebi.ac.uk/pdbsum/2b18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b18 ProSAT]</span></td></tr>
[[2b18]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B18 OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/CODY_BACSU CODY_BACSU] DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase and sporulation. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor.<ref>PMID:8830686</ref> <ref>PMID:11331605</ref>
<ref group="xtra">PMID:016488888</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b1/2b18_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b18 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Blagova, E.]]
[[Category: Large Structures]]
[[Category: Joseph, P.]]
[[Category: Blagova E]]
[[Category: Levdikov, V M.]]
[[Category: Joseph P]]
[[Category: Sonenshein, A L.]]
[[Category: Levdikov VM]]
[[Category: Wilkinson, A J.]]
[[Category: Sonenshein AL]]
[[Category: Branched chain amino acid binding.]]
[[Category: Wilkinson AJ]]
[[Category: Cody]]
[[Category: Dna-binding]]
[[Category: Gaf domain]]
[[Category: Nucleotide-binding]]
[[Category: Repressor]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
Retrieved from "https://proteopedia.org/2b18"