Sandbox Reserved 720: Difference between revisions
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'''Human Merlin FERM Domain''' | |||
<big>'''Human Merlin FERM Domain'''</big> | |||
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[[Image:structure2D.gif |thumb|left|230px|Human Merlin FERM Domains colored by chain]] | [[Image:structure2D.gif |thumb|left|230px|Human Merlin FERM Domains colored by chain]] | ||
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A mechanism that lowers merlin expression in breast cancer<ref>PMID:21965655</ref> is the phosphorylation at <scene name='Sandbox_Reserved_705/Resi/1'>Thr-230</scene> and <scene name='Sandbox_Reserved_705/Rez/1'>Ser-315</scene>. They target the protein for ubiquitination,degradation <ref>PMID:17891137</ref>. | A mechanism that lowers merlin expression in breast cancer<ref>PMID:21965655</ref> is the phosphorylation at <scene name='Sandbox_Reserved_705/Resi/1'>Thr-230</scene> and <scene name='Sandbox_Reserved_705/Rez/1'>Ser-315</scene>. They target the protein for ubiquitination,degradation <ref>PMID:17891137</ref>. | ||
However there exist many proteins that regulate merlin expression. They may all be | However there exist many proteins that regulate merlin expression. They may all be an useful therapetic target.Therefore further inverstigation are required to determine the pathways that involve the merlin protein. | ||
==External Resources== | ==External Resources== | ||
* See: [[Oncogenes & Tumor Suppressor Genes]] for Additional examples of oncogenes and tumor suppressor genes.<br /> | * See: [[Oncogenes & Tumor Suppressor Genes]] for Additional examples of oncogenes and tumor suppressor genes.<br /> | ||
* See: [[Cancer]] for Additional Proteins involved in the disease. <br /> | * See: [[Cancer]] for Additional Proteins involved in the disease. <br /> | ||
<ref group="xtra">PMID:22525268</ref><ref group="xtra">PMID:12356905</ref><ref group="xtra">PMID:12203111</ref><ref group="xtra">PMID:17134719</ref><ref group="xtra">PMID:14724586</ref><ref group="xtra">PMID:21402777</ref><ref group="xtra">PMID:10847681</ref> | |||
<references group="xtra"/> | <references group="xtra"/> | ||
== References == | |||
<references/> | |||
== Proteopedia Page Contributors and Editors == | |||
[[User:Xavière Lornage|Xavière Lornage]] and [[User:Kéliann Lesault|Kéliann Lesault]] | |||
[[Category:Homo sapiens]] | |||
[[Category:Tumor supressor]] | |||
[[Category:Ferm domain]] | |||
