2jtu: Difference between revisions

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~~[[Image:2jtu.png|left|200px]]~~

~~{{STRUCTURE_2jtu| PDB=2jtu | SCENE= }}~~

==NMR structure of iota-RXIA(38)==

===NMR structure of iota-RXIA(38)===

== Structural highlights ==

<table><tr><td colspan='2'>[[2jtu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JTU FirstGlance]. <br>

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>

==~~About this Structure~~==

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtu OCA], [https://pdbe.org/2jtu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jtu RCSB], [https://www.ebi.ac.uk/pdbsum/2jtu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jtu ProSAT]</span></td></tr>

[[2jtu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTU OCA].

</table>

[[Category: Norton, R.]]

== Function ==

[[Category: Wei, D.]]

[[https://www.uniprot.org/uniprot/CI1BA_CONRA CI1BA_CONRA]] Iota-conotoxins bind to voltage-gated sodium channels and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. This toxin acts on Nav1.6/SCN8A > Nav1.2/SCN2A > Nav1.7/SCN9A sodium channels. Produces general excitatory symptoms upon intracorporeal injection and repetitive action potentials in the frog cutaneous pectoris muscle. Natural peptide (with D-Phe) is active on nerve, but not on muscle. Synthetic peptide (with L-Phe) is not active on both nerve and muscle.<ref>PMID:17696362</ref> <ref>PMID:18486102</ref>

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

Check<jmol>

<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/2jtu_consurf.spt"</scriptWhenChecked>

<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>

<text>to colour the structure by Evolutionary Conservation</text>

</jmolCheckbox>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jtu ConSurf].

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Norton, R]]

[[Category: Wei, D]]

[[Category: Bromination]]

[[Category: D-amino acid]]

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@@ Line 1: / Line 1: @@
-[[Image:2jtu.png|left|200px]]
-{{STRUCTURE_2jtu|  PDB=2jtu  |  SCENE=  }}
+==NMR structure of iota-RXIA(38)==
+<StructureSection load='2jtu' size='340' side='right'caption='[[2jtu]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-===NMR structure of iota-RXIA(38)===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2jtu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JTU FirstGlance]. <br>
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jtu OCA], [https://pdbe.org/2jtu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jtu RCSB], [https://www.ebi.ac.uk/pdbsum/2jtu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jtu ProSAT]</span></td></tr>
-[[2jtu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JTU OCA].
+</table>
-[[Category: Norton, R.]]
+== Function ==
-[[Category: Wei, D.]]
+[[https://www.uniprot.org/uniprot/CI1BA_CONRA CI1BA_CONRA]] Iota-conotoxins bind to voltage-gated sodium channels and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. This toxin acts on Nav1.6/SCN8A > Nav1.2/SCN2A > Nav1.7/SCN9A sodium channels. Produces general excitatory symptoms upon intracorporeal injection and repetitive action potentials in the frog cutaneous pectoris muscle. Natural peptide (with D-Phe) is active on nerve, but not on muscle. Synthetic peptide (with L-Phe) is not active on both nerve and muscle.<ref>PMID:17696362</ref> <ref>PMID:18486102</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/2jtu_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jtu ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Norton, R]]
+[[Category: Wei, D]]
 [[Category: Bromination]]
 [[Category: D-amino acid]]