2l37: Difference between revisions
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==3D solution structure of arginine/glutamate-rich polypeptide Luffin P1 from the seeds of sponge gourd (Luffa cylindrical)== | |||
<StructureSection load='2l37' size='340' side='right'caption='[[2l37]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2l37]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Luffa_aegyptiaca Luffa aegyptiaca]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L37 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l37 OCA], [https://pdbe.org/2l37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l37 RCSB], [https://www.ebi.ac.uk/pdbsum/2l37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l37 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RIP1_LUFAE RIP1_LUFAE] Inhibits protein synthesis in animal cells.<ref>PMID:12948831</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Luffin P1, the smallest ribosome-inactivating peptide from the seeds of Luffa cylindrica was found to have anti-HIV-1 activity in HIV-1 infected C8166 T-cell lines and be able to bind with HIV Rev Response Element. Nuclear magnetic resonance spectroscopy revealed that the Luffin P1 comprises a helix-loop-helix motif, with the two alpha helices tightly associated by two disulfide bonds. Based on our findings, we conclude that unlike the well-studied ribosome-inactivating proteins, which exert their action through N-glycosidase activities, Luffin P1 demonstrates a novel inactivation mechanism probably through the charge complementation with viral or cellular proteins. Our work also provides a new scaffold for the design of novel inhibitors from a simple helical motif. | |||
Structural characterization and anti-HIV-1 activities of arginine/glutamate-rich polypeptide Luffin P1 from the seeds of sponge gourd (Luffa cylindrica).,Ng YM, Yang Y, Sze KH, Zhang X, Zheng YT, Shaw PC J Struct Biol. 2010 Dec 31. PMID:21195767<ref>PMID:21195767</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2l37" style="background-color:#fffaf0;"></div> | |||
== | ==See Also== | ||
[[ | *[[Ribosome inactivating protein 3D structures|Ribosome inactivating protein 3D structures]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Luffa aegyptiaca]] | [[Category: Luffa aegyptiaca]] | ||
[[Category: Ng YM]] | |||
[[Category: Ng | [[Category: Shaw PC]] | ||
[[Category: Shaw | [[Category: Sze KH]] | ||
[[Category: Sze | [[Category: Yang Y]] | ||
[[Category: Yang | [[Category: Zhang X]] | ||
[[Category: Zhang | [[Category: Zheng YT]] | ||
[[Category: Zheng | |||
Latest revision as of 08:16, 30 October 2024
3D solution structure of arginine/glutamate-rich polypeptide Luffin P1 from the seeds of sponge gourd (Luffa cylindrical)
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