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| [[Image:1gwl.gif|left|200px]]<br />
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| <applet load="1gwl" size="450" color="white" frame="true" align="right" spinBox="true"
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| caption="1gwl, resolution 1.51Å" />
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| '''CARBOHYDRATE BINDING MODULE FAMILY29 COMPLEXED WITH MANNOHEXAOSE'''<br />
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| ==Overview== | | ==Carbohydrate binding module family29 complexed with mannohexaose== |
| Carbohydrate-protein recognition is central to many biological processes., Enzymes that act on polysaccharide substrates frequently contain, noncatalytic domains, "carbohydrate-binding modules" (CBMs), that target, the enzyme to the appropriate substrate. CBMs that recognize specific, plant structural polysaccharides are often able to accommodate both the, variable backbone and the side-chain decorations of heterogeneous ligands., "CBM29" modules, derived from a noncatalytic component of the Piromyces, equi cellulase/hemicellulase complex, provide an example of this selective, yet flexible recognition. They discriminate strongly against some, polysaccharides while remaining relatively promiscuous toward both, beta-1,4-linked manno- and cello-oligosaccharides. This feature may, reflect ... [[http://ispc.weizmann.ac.il/pmbin/getpm?12391332 (full description)]]
| | <StructureSection load='1gwl' size='340' side='right'caption='[[1gwl]], [[Resolution|resolution]] 1.51Å' scene=''> |
| | | == Structural highlights == |
| ==About this Structure== | | <table><tr><td colspan='2'>[[1gwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Piromyces_sp._'equi' Piromyces sp. 'equi']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GWL FirstGlance]. <br> |
| 1GWL is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Piromyces_equi Piromyces equi]]. Structure known Active Site: BM1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GWL OCA]].
| | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.51Å</td></tr> |
| | | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene></td></tr> |
| ==Reference== | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwl OCA], [https://pdbe.org/1gwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gwl RCSB], [https://www.ebi.ac.uk/pdbsum/1gwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gwl ProSAT]</span></td></tr> |
| Promiscuity in ligand-binding: The three-dimensional structure of a Piromyces carbohydrate-binding module, CBM29-2, in complex with cello- and mannohexaose., Charnock SJ, Bolam DN, Nurizzo D, Szabo L, McKie VA, Gilbert HJ, Davies GJ, Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14077-82. Epub 2002 Oct 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12391332 12391332]
| | </table> |
| [[Category: Piromyces equi]]
| | == Function == |
| [[Category: Single protein]]
| | [https://www.uniprot.org/uniprot/Q9C171_PIREQ Q9C171_PIREQ] |
| [[Category: Charnock, S.J.]]
| | __TOC__ |
| [[Category: Davies, G.J.]]
| | </StructureSection> |
| [[Category: Nurizzo, D.]] | | [[Category: Large Structures]] |
| [[Category: carbohydrate binding domain]] | | [[Category: Piromyces sp. 'equi']] |
| [[Category: cellohexaose]] | | [[Category: Charnock SJ]] |
| [[Category: cellulosome]] | | [[Category: Davies GJ]] |
| [[Category: glucomannan]] | | [[Category: Nurizzo D]] |
| [[Category: mannohexaose]] | |
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| ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:21:24 2007''
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