2p7z: Difference between revisions

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[[Image:2p7z.png|left|200px]]


{{STRUCTURE_2p7z|  PDB=2p7z  |  SCENE=  }}
==Estrogen Related Receptor Gamma in complex with 4-hydroxy-tamoxifen==
 
<StructureSection load='2p7z' size='340' side='right'caption='[[2p7z]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
===Estrogen Related Receptor Gamma in complex with 4-hydroxy-tamoxifen===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2p7z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P7Z FirstGlance]. <br>
{{ABSTRACT_PUBMED_17964775}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OHT:4-HYDROXYTAMOXIFEN'>OHT</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7z OCA], [https://pdbe.org/2p7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p7z RCSB], [https://www.ebi.ac.uk/pdbsum/2p7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p7z ProSAT]</span></td></tr>
[[2p7z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7Z OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).<ref>PMID:19067653</ref> <ref>PMID:18063693</ref> <ref>PMID:11864604</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/2p7z_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p7z ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Estrogen-related receptor|Estrogen-related receptor]]
*[[Estrogen-related receptor 3D structures|Estrogen-related receptor 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:017964775</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Abad, M C.]]
[[Category: Large Structures]]
[[Category: Hormone receptor]]
[[Category: Abad MC]]
[[Category: Three layered alpha helical sandwich]]
Retrieved from "https://proteopedia.org/2p7z"