2i46: Difference between revisions

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[[Image:2i46.png|left|200px]]


{{STRUCTURE_2i46|  PDB=2i46  |  SCENE=  }}
==Crystal structure of human TPP1==
 
<StructureSection load='2i46' size='340' side='right'caption='[[2i46]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
===Crystal structure of human TPP1===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2i46]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I46 FirstGlance]. <br>
{{ABSTRACT_PUBMED_17237768}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i46 OCA], [https://pdbe.org/2i46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i46 RCSB], [https://www.ebi.ac.uk/pdbsum/2i46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i46 ProSAT]</span></td></tr>
==About this Structure==
</table>
[[2i46]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I46 OCA].  
== Function ==
[https://www.uniprot.org/uniprot/ACD_HUMAN ACD_HUMAN] Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis.<ref>PMID:15181449</ref> <ref>PMID:16166375</ref> <ref>PMID:16880378</ref> <ref>PMID:20231318</ref> <ref>PMID:17237768</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Baciu, P.]]
[[Category: Large Structures]]
[[Category: Cech, T R.]]
[[Category: Baciu P]]
[[Category: Else, T.]]
[[Category: Cech TR]]
[[Category: Hammer, G D.]]
[[Category: Else T]]
[[Category: Lei, M.]]
[[Category: Hammer GD]]
[[Category: Podell, E R.]]
[[Category: Lei M]]
[[Category: Wang, F.]]
[[Category: Podell ER]]
[[Category: Yang, Y T.]]
[[Category: Wang F]]
[[Category: Zaug, A J.]]
[[Category: Yang YT]]
[[Category: Ob fold]]
[[Category: Zaug AJ]]
[[Category: Pot1 binding]]
[[Category: Protein binding]]
[[Category: Tpp1]]
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