2fu4: Difference between revisions
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==Crystal Structure of the DNA binding domain of E.coli FUR (Ferric Uptake Regulator)== | |||
<StructureSection load='2fu4' size='340' side='right'caption='[[2fu4]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2fu4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21 Escherichia coli BL21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FU4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fu4 OCA], [https://pdbe.org/2fu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fu4 RCSB], [https://www.ebi.ac.uk/pdbsum/2fu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fu4 ProSAT]</span></td></tr> | ||
[[2fu4]] is a 2 chain structure with sequence from [ | </table> | ||
== Function == | |||
== | [https://www.uniprot.org/uniprot/FUR_ECOLI FUR_ECOLI] Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes. Regulates the expression of several outer-membrane proteins including the iron transport operon.<ref>PMID:2823881</ref> | ||
< | == Evolutionary Conservation == | ||
[[ | [[Image:Consurf_key_small.gif|200px|right]] | ||
[[ | Check<jmol> | ||
[[Category: | <jmolCheckbox> | ||
[[Category: | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fu/2fu4_consurf.spt"</scriptWhenChecked> | ||
[[Category: | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
[[Category: | <text>to colour the structure by Evolutionary Conservation</text> | ||
[[Category: | </jmolCheckbox> | ||
[[Category: | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fu4 ConSurf]. | ||
[[Category: | <div style="clear:both"></div> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Escherichia coli BL21]] | |||
[[Category: Large Structures]] | |||
[[Category: Bersch B]] | |||
[[Category: Brutscher B]] | |||
[[Category: D'Autreaux B]] | |||
[[Category: Dupuy J]] | |||
[[Category: Jacquamet L]] | |||
[[Category: Michaud-Soret I]] | |||
[[Category: Nicolet Y]] | |||
[[Category: Pecqueur L]] | |||
Latest revision as of 13:51, 13 March 2024
Crystal Structure of the DNA binding domain of E.coli FUR (Ferric Uptake Regulator)
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