2i6y: Difference between revisions
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==Structure and Mechanism of Mycobacterium tuberculosis Salicylate Synthase, MbtI== | |||
<StructureSection load='2i6y' size='340' side='right'caption='[[2i6y]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2i6y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I6Y FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i6y OCA], [https://pdbe.org/2i6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i6y RCSB], [https://www.ebi.ac.uk/pdbsum/2i6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i6y ProSAT], [https://www.topsan.org/Proteins/TBSGC/2i6y TOPSAN]</span></td></tr> | |||
== | </table> | ||
[[2i6y]] is a 1 chain structure with sequence from [ | == Function == | ||
[https://www.uniprot.org/uniprot/MBTI_MYCTU MBTI_MYCTU] Mediates the production of salicylate from chorismate via an isochorismate intermediate. Presents both isochorismate synthase and isochorismate-pyruvate lyase activities. Salycilate is the starter unit in the production of the virulence-conferring salicylate-based siderophore mycobactin.<ref>PMID:16923875</ref> | |||
== | == Evolutionary Conservation == | ||
< | [[Image:Consurf_key_small.gif|200px|right]] | ||
[[Category: | Check<jmol> | ||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i6/2i6y_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i6y ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Kisker | [[Category: Kisker C]] | ||
[[Category: Subramaniapillai | [[Category: Subramaniapillai K]] | ||
[[Category: Tonge | [[Category: Tonge PJ]] | ||
[[Category: Zhou | [[Category: Zhou R]] | ||
[[Category: Zwahlen | [[Category: Zwahlen J]] | ||
Latest revision as of 09:01, 21 February 2024
Structure and Mechanism of Mycobacterium tuberculosis Salicylate Synthase, MbtI
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