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[[Image:2gvg.png|left|200px]]


{{STRUCTURE_2gvg|  PDB=2gvg  |  SCENE=  }}
==Crystal Structure of human NMPRTase and its complex with NMN==
 
<StructureSection load='2gvg' size='340' side='right'caption='[[2gvg]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
===Crystal Structure of human NMPRTase and its complex with NMN===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2gvg]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GVG FirstGlance]. <br>
{{ABSTRACT_PUBMED_16783377}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gvg OCA], [https://pdbe.org/2gvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gvg RCSB], [https://www.ebi.ac.uk/pdbsum/2gvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gvg ProSAT]</span></td></tr>
[[2gvg]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GVG OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gv/2gvg_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gvg ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Phosphoribosyltransferase|Phosphoribosyltransferase]]
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:016783377</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Nicotinamide phosphoribosyltransferase]]
[[Category: Large Structures]]
[[Category: Khan, J A.]]
[[Category: Khan JA]]
[[Category: Tao, X.]]
[[Category: Tao X]]
[[Category: Tong, L.]]
[[Category: Tong L]]
[[Category: Cancer]]
[[Category: Crystal]]
[[Category: Nmprtase]]
[[Category: Pbef]]
[[Category: Transferase]]
[[Category: Visfatin]]
Retrieved from "https://proteopedia.org/2gvg"