2h3u: Difference between revisions

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[[Image:2h3u.png|left|200px]]


{{STRUCTURE_2h3u|  PDB=2h3u  |  SCENE=  }}
==Crystal structure of murine carnitine acetyltransferase in complex with carnitine and CoA==
 
<StructureSection load='2h3u' size='340' side='right'caption='[[2h3u]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
===Crystal structure of murine carnitine acetyltransferase in complex with carnitine and CoA===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2h3u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H3U FirstGlance]. <br>
{{ABSTRACT_PUBMED_16870616}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=152:CARNITINE'>152</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h3u OCA], [https://pdbe.org/2h3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h3u RCSB], [https://www.ebi.ac.uk/pdbsum/2h3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h3u ProSAT]</span></td></tr>
[[2h3u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H3U OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/CACP_MOUSE CACP_MOUSE] Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h3/2h3u_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h3u ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Carnitine acetyltransferase|Carnitine acetyltransferase]]
*[[Carnitine acetyltransferase|Carnitine acetyltransferase]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:016870616</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Hsiao, Y S.]]
[[Category: Hsiao YS]]
[[Category: Jogl, G.]]
[[Category: Jogl G]]
[[Category: Tong, L.]]
[[Category: Tong L]]
[[Category: Carnitine acyltransferase]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/2h3u"