2h3u: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "2h3u" [edit=sysop:move=sysop] |
No edit summary |
||
| (7 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Crystal structure of murine carnitine acetyltransferase in complex with carnitine and CoA== | |||
<StructureSection load='2h3u' size='340' side='right'caption='[[2h3u]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2h3u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H3U FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=152:CARNITINE'>152</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h3u OCA], [https://pdbe.org/2h3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h3u RCSB], [https://www.ebi.ac.uk/pdbsum/2h3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h3u ProSAT]</span></td></tr> | ||
[[2h3u]] is a 2 chain structure with sequence from [ | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CACP_MOUSE CACP_MOUSE] Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h3/2h3u_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h3u ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Carnitine acetyltransferase|Carnitine acetyltransferase]] | *[[Carnitine acetyltransferase|Carnitine acetyltransferase]] | ||
__TOC__ | |||
</StructureSection> | |||
< | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Hsiao | [[Category: Hsiao YS]] | ||
[[Category: Jogl | [[Category: Jogl G]] | ||
[[Category: Tong | [[Category: Tong L]] | ||
Latest revision as of 09:30, 14 February 2024
Crystal structure of murine carnitine acetyltransferase in complex with carnitine and CoA
| ||||||||||||
