2f1s: Difference between revisions

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[[Image:2f1s.png|left|200px]]


{{STRUCTURE_2f1s|  PDB=2f1s  |  SCENE=  }}
==Crystal Structure of a Viral FLIP MC159==
 
<StructureSection load='2f1s' size='340' side='right'caption='[[2f1s]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
===Crystal Structure of a Viral FLIP MC159===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2f1s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Molluscum_contagiosum_virus_subtype_1 Molluscum contagiosum virus subtype 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F1S FirstGlance]. <br>
{{ABSTRACT_PUBMED_16317000}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f1s OCA], [https://pdbe.org/2f1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f1s RCSB], [https://www.ebi.ac.uk/pdbsum/2f1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f1s ProSAT]</span></td></tr>
==About this Structure==
</table>
[[2f1s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Molluscum_contagiosum_virus_subtype_1 Molluscum contagiosum virus subtype 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F1S OCA].  
== Function ==
 
[https://www.uniprot.org/uniprot/CFLA_MCV1 CFLA_MCV1] Inhibits TNFRSF1A, TNFRSF6 and TNFRSF12 induced apoptosis. May interfere with caspase-8 recruitment and activation at the death-inducing signaling complex (DISC). May lead to higher virus production and contribute to virus persistence and oncogenicity.<ref>PMID:9087414</ref> <ref>PMID:9037025</ref>
==Reference==
== Evolutionary Conservation ==
<ref group="xtra">PMID:016317000</ref><references group="xtra"/>
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f1/2f1s_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f1s ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Molluscum contagiosum virus subtype 1]]
[[Category: Molluscum contagiosum virus subtype 1]]
[[Category: Jeffrey, P D.]]
[[Category: Jeffrey PD]]
[[Category: Li, F Y.]]
[[Category: Li F-Y]]
[[Category: Shi, Y.]]
[[Category: Shi Y]]
[[Category: Yu, J W.]]
[[Category: Yu JW]]
[[Category: Apoptosis]]
[[Category: Caspase activation]]
[[Category: Death receptor signaling]]
[[Category: Ded]]
[[Category: Disc]]
[[Category: Flip]]
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