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[[Image:1wi8.jpg|left|200px]]<br /><applet load="1wi8" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1wi8" />
'''Solution structure of the RNA binding domain of eukaryotic initiation factor 4B'''<br />


==About this Structure==
==Solution structure of the RNA binding domain of eukaryotic initiation factor 4B==
1WI8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI8 OCA].  
<StructureSection load='1wi8' size='340' side='right'caption='[[1wi8]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1wi8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WI8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wi8 OCA], [https://pdbe.org/1wi8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wi8 RCSB], [https://www.ebi.ac.uk/pdbsum/1wi8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wi8 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wi8 TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IF4B_HUMAN IF4B_HUMAN] Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/1wi8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wi8 ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Inoue, M.]]
[[Category: Inoue M]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Muto, Y.]]
[[Category: Muto Y]]
[[Category: Nagata, T.]]
[[Category: Nagata T]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Shirouzu M]]
[[Category: Shirouzu, M.]]
[[Category: Suzuki S]]
[[Category: Suzuki, S.]]
[[Category: Terada T]]
[[Category: Terada, T.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: rbd]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rna binding domain]]
[[Category: rna recognition motif]]
[[Category: rnp]]
[[Category: rrm]]
[[Category: rsgi]]
[[Category: structural genomics]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:44:42 2008''
Retrieved from "https://proteopedia.org/1wi8"