2o3k: Difference between revisions

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[[Image:2o3k.png|left|200px]]


{{STRUCTURE_2o3k| PDB=2o3k | SCENE= }}
==Yeast Cytosine Deaminase D92E Triple Mutant bound to transition state analogue HPY==
<StructureSection load='2o3k' size='340' side='right'caption='[[2o3k]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2o3k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O3K FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HPY:4-HYDROXY-3,4-DIHYDRO-1H-PYRIMIDIN-2-ONE'>HPY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o3k OCA], [https://pdbe.org/2o3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o3k RCSB], [https://www.ebi.ac.uk/pdbsum/2o3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o3k ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FCY1_YEAST FCY1_YEAST] Converts cytosine to uracil or 5-methylcytosine to thymine by deaminating carbon number 4.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o3/2o3k_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o3k ConSurf].
<div style="clear:both"></div>


===Yeast Cytosine Deaminase D92E Triple Mutant bound to transition state analogue HPY===
==See Also==
 
*[[Deaminase 3D structures|Deaminase 3D structures]]
{{ABSTRACT_PUBMED_018291415}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[2o3k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O3K OCA].
[[Category: Cytosine deaminase]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Korkegian, A M.]]
[[Category: Korkegian AM]]
[[Category: Stoddard, B L.]]
[[Category: Stoddard BL]]
[[Category: Homodimer]]
[[Category: Hydrolase]]
[[Category: Transition state analogue]]
Retrieved from "https://proteopedia.org/2o3k"