2k5t: Difference between revisions

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[[Image:2k5t.png|left|200px]]


{{STRUCTURE_2k5t|  PDB=2k5t  |  SCENE=  }}
==Solution NMR Structure of Putative N-Acetyl Transferase YhhK from E. coli Bound to Coenzyme A: Northeast Structural Genomics Consortium Target ET106==
 
<StructureSection load='2k5t' size='340' side='right'caption='[[2k5t]]' scene=''>
===Solution NMR Structure of Putative N-Acetyl Transferase YhhK from E. coli Bound to Coenzyme A: Northeast Structural Genomics Consortium Target ET106===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2k5t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K5T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K5T FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
[[2k5t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K5T OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k5t OCA], [https://pdbe.org/2k5t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k5t RCSB], [https://www.ebi.ac.uk/pdbsum/2k5t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k5t ProSAT], [https://www.topsan.org/Proteins/NESGC/2k5t TOPSAN]</span></td></tr>
[[Category: Escherichia coli k-12]]
</table>
[[Category: Arrowsmith, C H.]]
== Function ==
[[Category: Cort, J R.]]
[https://www.uniprot.org/uniprot/PANZ_ECOLI PANZ_ECOLI] Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion. Binding of CoA or a derivative to PanZ leads to interaction with PanD, which promotes the processing and activation of pro-PanD, and subsequent substrate-mediated inhibition of the active form of PanD (PubMed:23170229, PubMed:25910242). Inhibition of PanD activity is probably the primary metabolic role of PanZ, allowing negative feedback regulation of pantothenate biosynthesis by CoA (PubMed:25910242).<ref>PMID:23170229</ref> <ref>PMID:25910242</ref>
[[Category: Kennedy, M A.]]
== Evolutionary Conservation ==
[[Category: Montelione, G T.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
Check<jmol>
[[Category: Yee, A.]]
  <jmolCheckbox>
[[Category: Bound ligand]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k5/2k5t_consurf.spt"</scriptWhenChecked>
[[Category: Coa]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Coenzyme some]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: N-acetyl transferase]]
  </jmolCheckbox>
[[Category: Nesg]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k5t ConSurf].
[[Category: Northeast structural genomics consortium]]
<div style="clear:both"></div>
[[Category: Protein structure initiative]]
== References ==
[[Category: Psi-2]]
<references/>
[[Category: Structural genomic]]
__TOC__
[[Category: Transferase]]
</StructureSection>
[[Category: Unknown function]]
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Cort JR]]
[[Category: Kennedy MA]]
[[Category: Montelione GT]]
[[Category: Yee A]]
Retrieved from "https://proteopedia.org/2k5t"