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[[Image:2ko1.png|left|200px]]


{{STRUCTURE_2ko1|  PDB=2ko1  |  SCENE=  }}
==Solution NMR structure of the ACT domain from GTP pyrophosphokinase of Chlorobium tepidum. Northeast Structural Genomics Consortium Target CtR148A==
 
<StructureSection load='2ko1' size='340' side='right'caption='[[2ko1]]' scene=''>
===Solution NMR structure of the ACT domain from GTP pyrophosphokinase of Chlorobium tepidum. Northeast Structural Genomics Consortium Target CtR148A===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2ko1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlorobaculum_tepidum Chlorobaculum tepidum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KO1 FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ko1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ko1 OCA], [https://pdbe.org/2ko1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ko1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ko1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ko1 ProSAT]</span></td></tr>
[[2ko1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chlorobaculum_tepidum Chlorobaculum tepidum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KO1 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8KC80_CHLTE Q8KC80_CHLTE] In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity).[RuleBase:RU003847]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/2ko1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ko1 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Chlorobaculum tepidum]]
[[Category: Chlorobaculum tepidum]]
[[Category: GTP diphosphokinase]]
[[Category: Large Structures]]
[[Category: Acton, T B.]]
[[Category: Acton TB]]
[[Category: Ciccosanti, C.]]
[[Category: Ciccosanti C]]
[[Category: Eletsky, A.]]
[[Category: Eletsky A]]
[[Category: Everett, J K.]]
[[Category: Everett JK]]
[[Category: Garcia, E.]]
[[Category: Garcia E]]
[[Category: Jiang, M.]]
[[Category: Jiang M]]
[[Category: Lee, H.]]
[[Category: Lee H]]
[[Category: Montelione, G T.]]
[[Category: Montelione GT]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Nair R]]
[[Category: Nair, R.]]
[[Category: Prestegard JH]]
[[Category: Prestegard, J H.]]
[[Category: Rost B]]
[[Category: Rost, B.]]
[[Category: Szyperski T]]
[[Category: Szyperski, T.]]
[[Category: Wang H]]
[[Category: Wang, H.]]
[[Category: Xiao R]]
[[Category: Xiao, R.]]
[[Category: Alpha+beta]]
[[Category: Homodimer]]
[[Category: Kinase]]
[[Category: Nesg]]
[[Category: Northeast structural genomics consortium]]
[[Category: Protein structure initiative]]
[[Category: Psi-2]]
[[Category: Structural genomic]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/2ko1"