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[[Image:2frh.png|left|200px]]


{{STRUCTURE_2frh|  PDB=2frh  |  SCENE=  }}
==Crystal Structure of Sara, A Transcription Regulator From Staphylococcus Aureus==
 
<StructureSection load='2frh' size='340' side='right'caption='[[2frh]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
===Crystal Structure of Sara, A Transcription Regulator From Staphylococcus Aureus===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2frh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FRH FirstGlance]. <br>
{{ABSTRACT_PUBMED_16455801}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2frh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2frh OCA], [https://pdbe.org/2frh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2frh RCSB], [https://www.ebi.ac.uk/pdbsum/2frh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2frh ProSAT]</span></td></tr>
[[2frh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FRH OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/SARA_STAAW SARA_STAAW] Global regulator with both positive and negative effects that controls the expression of several virulence factors and the biofilm formation process in a cell density-dependent manner (By similarity). Required for transcription of primary transcripts RNAII and RNAIII generated by agr (virulence accessory gene regulator) locus. Negatively regulates the expression of spa (protein A) and aur (metalloprotease aureolysin).
<ref group="xtra">PMID:016455801</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fr/2frh_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2frh ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Cheung, A L.]]
[[Category: Cheung AL]]
[[Category: Ingavale, S.]]
[[Category: Ingavale S]]
[[Category: Liu, Y.]]
[[Category: Liu Y]]
[[Category: Manna, A C.]]
[[Category: Manna AC]]
[[Category: Zhang, G.]]
[[Category: Zhang G]]
[[Category: Divalent metal binding]]
[[Category: Transcription]]
[[Category: Winged-helix protein]]
Retrieved from "https://proteopedia.org/2frh"